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Molecular Profile | KMT2A rearrange |
Therapy | Revumenib |
Indication/Tumor Type | acute leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange | acute leukemia | predicted - sensitive | Revumenib | Phase I | Actionable | In a Phase I trial (AUGMENT 101), Revumenib treatment demonstrated acceptable safety and promising antileukemic activity in patients with acute leukemia harboring KMT2A rearrangements, and led to a composite complete response rate of 49% (17/35) (Blood (2021) 138 (Supplement 1): 699). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Safety and Efficacy of Menin Inhibition in Patients (Pts) with MLL-Rearranged and NPM1 Mutant Acute Leukemia: A Phase (Ph) 1, First-in-Human Study of SNDX-5613 (AUGMENT 101) | Full reference... |