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|Molecular Profile||EML4 - ALK ALK I1171N ALK L1196M ALK G1202R|
|Indication/Tumor Type||malignant pleural mesothelioma|
|Response Type||predicted - resistant|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EML4 - ALK ALK I1171N ALK L1196M ALK G1202R||malignant pleural mesothelioma||predicted - resistant||Lorlatinib||Case Reports/Case Series||Actionable||In a clinical case study, ALK G1202R was identified in the post-progression biopsy of a patient with malignant pleural mesothelioma harboring EML4-ALK with ALK L1196M and ALK I1171N who previously responded to Lorbrena (lorlatinib) treatment (PMID: 32600123).||32600123|
|PubMed Id||Reference Title||Details|
|(32600123)||Acquired multiple mutations ALK I1171N, L1196M and G1202R mediate lorlatinib resistance in EML4-ALK-rearranged malignant pleural mesothelioma: a case report.||Full reference...|