Profile Response Detail


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Molecular Profile CD274 positive
Therapy Carboplatin + Fluorouracil + Pembrolizumab
Indication/Tumor Type head and neck squamous cell carcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive head and neck squamous cell carcinoma sensitive Carboplatin + Fluorouracil + Pembrolizumab Guideline Actionable Keytruda (pembrolizumab) in combination with platinum and Adrucil (fluorouracil) is included in the Pan-Asian Guidelines Adaptation (PAGA) for patients with CD274 (PD-L1)-positive (CPS >/=1) recurrent or metastatic head and neck squamous cell carcinoma (PMID: 34844180; 34844180 detail...
PubMed Id Reference Title Details
ESMO Clinical Practice Guidelines Full reference...
(34844180) Pan-Asian adaptation of the EHNS-ESMO-ESTRO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with squamous cell carcinoma of the head and neck. Full reference...