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Molecular Profile TP53 mutant
Therapy Acalabrutinib
Indication/Tumor Type chronic lymphocytic leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant chronic lymphocytic leukemia sensitive Acalabrutinib Guideline Actionable Calquence (acalabrutinib) is included in the guidelines as first-line therapy for patients with advanced chronic lymphocytic leukemia harboring TP53 mutations and for patients with relapsed or refractory disease (PMID: 33091559; ESMO.org). 33091559 detail...
PubMed Id Reference Title Details
ESMO Clinical Practice Guidelines Full reference...
(33091559) Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Full reference...