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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||lung squamous cell carcinoma||not applicable||Cisplatin + Gemcitabine + Necitumumab||FDA approved||Actionable||In a Phase III clinical trial that supported FDA approval, treatment with Portrazza (necitumumab), in combination with gemcitabine and cisplatin, resulted in an increased median overall survival of 11.5 months in squamous NSCLC patients, compared to 9.9 months with gemcitabine and cisplatin alone (PMID: 26045340).||detail... 26045340|
|PubMed Id||Reference Title||Details|
|(26045340)||Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial.||Full reference...|
|Portrazza (necitumumab) FDA Drug Label||Full reference...|