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Molecular Profile BRAF act mut
Therapy CC-91516
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF act mut colorectal cancer predicted - sensitive CC-91516 Preclinical - Biochemical Actionable In a preclinical study, CC-91516 inhibited Mapk signaling in BRAF-mutant colorectal cancer cells (Cancer Res 2022;82(12_Suppl):Abstract nr 1180). detail...
PubMed Id Reference Title Details
Discovery of CC-91516, a potent and selective ERK/NLK inhibitor, with anti-tumor activity in preclinical cancer models harboring BRAF or CTNNB1 mutation Full reference...