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Molecular Profile FLT3 exon 14 ins
Therapy Saridegib + Sorafenib
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins acute myeloid leukemia sensitive Saridegib + Sorafenib Preclinical - Cell culture Actionable In a preclinical study, treatment with the combination of Nexavar (sorafenib) and Saridegib (IPI-926) resulted in significantly decreased cell proliferation compared to Nexavar (sorafenib) alone in two acute myeloid leukemia cell lines harboring FLT3-ITD mutations in culture (PMID: 26062848). 26062848
PubMed Id Reference Title Details
(26062848) Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Full reference...