Profile Response Detail

Molecular Profile MET N375S
Therapy SU11274
Indication/Tumor Type Advanced Solid Tumor
Response Type decreased response
Create By spatterson
Update By spatterson

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MET N375S Advanced Solid Tumor decreased response SU11274 Preclinical Actionable In a preclinical study, cells expressing MET N375S had decreased sensitivity to SU11274 in culture compared to cells expressing wild-type MET (PMID: 19723643). 19723643
PubMed Id Reference Title Details
(19723643) Ethnic differences and functional analysis of MET mutations in lung cancer. Full reference...