Profile Response Detail


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Molecular Profile KMT2A - AFF1
Therapy DSP-5336
Indication/Tumor Type leukemia
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A - AFF1 leukemia predicted - sensitive DSP-5336 Preclinical - Pdx & cell culture Actionable In a preclinical study, DSP-5336 treatment inhibited growth of a leukemia cell line harboring KMT2A-AFF1 (reported as MLL-AF4) in culture, led to antitumor activity in a cell line xenograft model, and resulted in remission and improved survival in a patient-derived xenograft (PDX) model (Blood (2021) 138 (Supplement 1): 3339). detail...
PubMed Id Reference Title Details
Preclinical Evaluation of a Novel Orally Bioavailable Menin-MLL Interaction Inhibitor, DSP-5336, for the Treatment of Acute Leukemia Patients with MLL-Rearrangement or NPM1 Mutation Full reference...