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Molecular Profile PTPN11 act mut
Therapy Refametinib
Indication/Tumor Type lung non-small cell carcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTPN11 act mut lung non-small cell carcinoma sensitive Refametinib Preclinical Actionable In a preclinical study, Refemetinib (BAY86-9766) inhibited growth of NSCLC cells harboring activating PTPN11 mutations in culture (J Clin Oncol 33, 2015(Suppl; abstr 11077)). detail...
PubMed Id Reference Title Details
Protein tyrosine phosphatase non receptor 11 (PTPN11/Shp2) as a driver oncogene and a novel therapeutic target in non-small cell lung cancer (NSCLC) Full reference...