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Molecular Profile FLT3 exon 14 ins FLT3 D835Y
Therapy Sorafenib
Indication/Tumor Type hematologic cancer
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 D835Y hematologic cancer resistant Sorafenib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing FLT3-ITD and FLT3 D835Y demonstrated resistance to Nexavar (sorafenib) in culture (PMID: 34768286). 34768286
PubMed Id Reference Title Details
(34768286) Momelotinib is a highly potent inhibitor of FLT3-mutant AML. Full reference...