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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KIT V560D KIT D820A||gastrointestinal stromal tumor||resistant||Imatinib||Case Reports/Case Series||Actionable||In a clinical study, KIT D820A was identified as a secondary mutation in a patient with gastrointestinal stromal tumor harboring a primary KIT V560D mutation, who developed resistance to Gleevec (imatinib mesylate) (PMID: 16954519).||16954519|
|KIT V560D KIT D820A||gastrointestinal stromal tumor||resistant||Imatinib||Preclinical||Actionable||In a preclinical study, a gastrointestinal stromal tumor cell line harboring KIT V560D and KIT D820A demonstrated resistance to Gleevec (imatinib) in culture (PMID: 16954519).||16954519|