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Molecular Profile EML4 - ALK ALK L1196M
Therapy Brigatinib
Indication/Tumor Type large cell neuroendocrine carcinoma
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK ALK L1196M large cell neuroendocrine carcinoma no benefit Brigatinib Case Reports/Case Series Actionable In a clinical case study, a heavily pretreated patient with metastatic large cell neuroendocrine lung carcinoma harboring EML4-ALK (e20:e20) and ALK L1196M did respond to Alunbrig (brigatinib) treatment (PMID: 36207130). 36207130
PubMed Id Reference Title Details
(36207130) Lorlatinib and compound mutations in ALK+ large-cell neuroendocrine lung carcinoma: a case report. Full reference...