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Molecular Profile BRAF T599dup
Therapy Dabrafenib + Trametinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF T599dup lung adenocarcinoma predicted - sensitive Dabrafenib + Trametinib Case Reports/Case Series Actionable In a clinical case study, a patient with lung adenocarcinoma harboring BRAF T599dup demonstrated a response to the combination of Tafinlar (dabrafenib) and Mekinist (trametinib), with regression of the left lower lobe bronchial tumor (PMID: 33704186). 33704186
PubMed Id Reference Title Details
(33704186) A Rare p.T599dup BRAF Mutant NSCLC in a Non-Smoker. Full reference...