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Molecular Profile KIT V560D KIT D820A
Therapy Imatinib + Infigratinib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT V560D KIT D820A gastrointestinal stromal tumor predicted - sensitive Imatinib + Infigratinib Preclinical - Cell line xenograft Actionable In a preclinical study, combination treatment with Gleevec (imatinib) and Truseltiq (infigratinib) treatment resulted in tumor shrinkage in a gastrointestinal stromal tumor cell line xenograft model harboring KIT V560D and KIT D820A (PMID: 35625872). 35625872
PubMed Id Reference Title Details
(35625872) In Vivo Evaluation of Fibroblast Growth Factor Receptor Inhibition in Mouse Xenograft Models of Gastrointestinal Stromal Tumor. Full reference...