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Molecular Profile | FGFR3 - TACC3 |
Therapy | AZD4547 |
Indication/Tumor Type | high grade glioma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 - TACC3 | high grade glioma | sensitive | AZD4547 | Preclinical - Cell culture | Actionable | In a preclinical study, AZD4547 inhibited Fgfr3 kinase activity in transformed astrocytes expressing the FGFR3-TACC3 fusion in culture (PMID: 22837387). | 22837387 |
PubMed Id | Reference Title | Details |
---|---|---|
(22837387) | Transforming fusions of FGFR and TACC genes in human glioblastoma. | Full reference... |