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Molecular Profile FGFR3 - TACC3
Therapy Infigratinib
Indication/Tumor Type high grade glioma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 - TACC3 high grade glioma sensitive Infigratinib Case Reports/Case Series Actionable In a Phase II trial, Truseltiq (infigratinib) treatment resulted in limited efficacy with a 6-month progression-free survival (PFS) rate of 16.0%, a median PFS of 1.7 months, an objective response rate of 4.8% (1/21), and median overall survival of 6.7 months in patients with recurrent glioma harboring alterations in FGFR1 or FGFR3, however, resulted in stable disease with PFS of 30.2 months in a patient harboring FGFR3-TACC3 (PMID: 35344029; NCT01975701). 35344029
FGFR3 - TACC3 high grade glioma sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, Truseltiq (infigratinib) inhibited Fgfr3 kinase activity in transformed astrocytes expressing the FGFR3-TACC3 fusion in culture (PMID: 22837387). 22837387
FGFR3 - TACC3 high grade glioma sensitive Infigratinib Preclinical - Pdx Actionable In a preclinical study, Truseltiq (infigratinib) treatment inhibited tumor growth in a patient-derived xenograft (PDX) model of glioma harboring FGFR3-TACC3 (Cancer Res 2019;79(13 Suppl):Abstract nr 2206). detail...
PubMed Id Reference Title Details
(22837387) Transforming fusions of FGFR and TACC genes in human glioblastoma. Full reference...
Anti-tumor activity of infigratinib, a potent and selective inhibitor of FGFR1, FGFR2 and FGFR3, in FGFR fusion-positive cholangiocarcinoma and other solid tumors Full reference...
(35344029) Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study. Full reference...