Profile Response Detail

Molecular Profile KRAS G12D
Therapy AZD8055 + MK-1775
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By spatterson
Update By spatterson


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS G12D Advanced Solid Tumor sensitive AZD8055 + MK-1775 Preclinical Actionable In a preclinical study, AZD8055 worked synergistically with MK-1775 to inhibit proliferation and promote apoptosis in transformed cells expressing KRAS G12D in culture (PMID: 24791855). 24791855
PubMed Id Reference Title Details
(24791855) Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. Full reference...