Profile Response Detail

Molecular Profile KRAS mutant
Therapy Cobimetinib + GDC-0068
Indication/Tumor Type Advanced Solid Tumor
Response Type predicted - sensitive
Create By spatterson
Update By djd


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant Advanced Solid Tumor predicted - sensitive Cobimetinib + GDC-0068 Phase I Actionable In a Phase I trial, the combination of Ipatasertib (GDC-0068) and Cobimetinib (GDC-0973) demonstrated safety and preliminary efficacy in patients with advanced solid tumors, including patients harboring KRAS mutations (Cancer Res, October 1, 2014 74; CT328). detail...
PubMed Id Reference Title Details
Abstract CT328: Clinical results of a phase Ib dose-escalation study of the Mek inhibitor cobimetinib (GDC-0973) and the Akt inhibitor ipatasertib (GDC-0068) in patients (pts) with solid tumors Full reference...