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Molecular Profile | EML4 - ALK ALK G1202R |
Therapy | NUV-655 |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK G1202R | lung non-small cell carcinoma | predicted - sensitive | NUV-655 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, NUV-655 demonstrated activity in a patient-derived non-small cell lung cancer cell line harboring EML4-ALK with ALK G1202R in culture and induced tumor regression in a patient-derived xenograft (PDX) model (Eur J Cancer 2022 Vol 174, Supp 1:S78-S79). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Preclinical activity of NVL-655 in patient-derived models of ALK cancers, including those with lorlatinib-resistant G1202R/L1196M compound mutation | Full reference... |