Profile Response Detail

Molecular Profile KRAS mutant
Therapy SAR245409 + Pimasertib
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By smockus
Update By smockus

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant colorectal cancer sensitive SAR245409 + Pimasertib Phase Ib/II Actionable In a Phase Ib trial, XL765 (SAR245409) in combination with, Pimasertib (MSC1936369B), demonstrated safety and preliminary efficacy in Kras mutant colorectal patients (Cancer Res 2013;73(8 Suppl):Abstract nr LB-147). detail...
PubMed Id Reference Title Details
Combination of the MEK inhibitor, pimasertib (MSC1936369B), and the PI3K/mTOR inhibitor, SAR245409, in patients with advanced solid tumors: Results of a phase Ib dose-escalation trial. Full reference...