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Molecular Profile IDH1 R132H
Therapy Pamiparib + Radiotherapy
Indication/Tumor Type high grade glioma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132H high grade glioma sensitive Pamiparib + Radiotherapy Preclinical - Cell line xenograft Actionable In a preclinical study, treatment with Pamiparib (BGB-290) enhanced the sensitivity of a glioma cell line expressing IDH1 R132H to radiation therapy, resulting in a reduction in tumor volume and increased survival compared to radiation therapy alone in a cell line xenograft model (PMID: 32494639). 32494639
PubMed Id Reference Title Details
(32494639) Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas. Full reference...