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Molecular Profile IDH1 R132H IDH1 T313I
Therapy IDH305
Indication/Tumor Type leukemia
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132H IDH1 T313I leukemia predicted - resistant IDH305 Preclinical - Biochemical Actionable In a preclinical study, IDH305 did not inhibit R-2HG production in a leukemia cell line expressing IDH1 R132H and T313I in culture (PMID: 36222845). 36222845
PubMed Id Reference Title Details
(36222845) Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance. Full reference...