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Molecular Profile ARID1A A35Gfs*76
Therapy Pamiparib
Indication/Tumor Type cholangiocarcinoma
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A A35Gfs*76 cholangiocarcinoma no benefit Pamiparib Preclinical - Patient cell culture Actionable In a preclinical study, a cholangiocarcinoma patient-derived xenograft (PDX) cell line harboring ARID1A A35Gfs*76 was insensitive to Pamiparib (BGB-290) in culture (PMID: 36374558). 36374558
PubMed Id Reference Title Details
(36374558) Human Metastatic Cholangiocarcinoma Patient-Derived Xenografts and Tumoroids for Preclinical Drug Evaluation. Full reference...