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Molecular Profile | Unknown unknown |
Therapy | Tirapazamine |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | triple-receptor negative breast cancer | not applicable | Tirapazamine | Preclinical | Actionable | In a preclinical study, Tirazone (tirapazamine) inhibited growth of triple-receptor negative breast cancer cell lines under hypoxic culture conditions, regardless of their BRCA1 status (PMID: 25193512). | 25193512 |
PubMed Id | Reference Title | Details |
---|---|---|
(25193512) | Dual targeting of hypoxia and homologous recombination repair dysfunction in triple-negative breast cancer. | Full reference... |