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Molecular Profile BRAF V600E
Therapy Celecoxib + Gefitinib + Trametinib + Vemurafenib
Indication/Tumor Type colorectal cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E colorectal cancer sensitive Celecoxib + Gefitinib + Trametinib + Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, the addition of Celecoxib to the combination of Zelboraf (vemurafenib), Mekinist (trametinib), and Iressa (gefitinib) synergistically inhibited viability in colorectal cancer cell lines harboring BRAF V600E in culture (PMID: 36759733). 36759733
PubMed Id Reference Title Details
(36759733) A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors. Full reference...