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Molecular Profile TP53 mutant
Therapy Nutlin-3a
Indication/Tumor Type neuroblastoma
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 mutant neuroblastoma resistant Nutlin-3a Preclinical Actionable In a preclinical study, neuroblastoma cell lines harboring TP53 mutant were resistant to nutlin-3 mediated growth inhibition (PMID: 21725357). 21725357
PubMed Id Reference Title Details
(21725357) MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63. Full reference...