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Molecular Profile | ERBB2 T798M |
Therapy | Lapatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ERBB2 T798M | Advanced Solid Tumor | resistant | Lapatinib | Preclinical | Actionable | In a preclinical study, transformed cell lines expressing ERBB2 (HER2) T798M demonstrated resistance when treated with Tykerb (lapatinib) in culture (PMID: 22046346). | 22046346 |
PubMed Id | Reference Title | Details |
---|---|---|
(22046346) | Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. | Full reference... |