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Molecular Profile | ERBB2 T862A |
Therapy | Lapatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ERBB2 T862A | Advanced Solid Tumor | predicted - sensitive | Lapatinib | Preclinical | Actionable | In a preclinical study, higher dose of Tykerb (lapatinib) inhibited proliferation of transformed cell lines expressing ERBB2 (HER2) N862A in culture (PMID: 22046346). | 22046346 |
ERBB2 T862A | Advanced Solid Tumor | predicted - sensitive | Lapatinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing ERBB2 (HER2) T862A demonstrated partial sensitivity to Tykerb (lapatinib) treatment in culture (PMID: 29967253). | 29967253 |
PubMed Id | Reference Title | Details |
---|---|---|
(22046346) | Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. | Full reference... |
(29967253) | High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2. | Full reference... |