Profile Response Detail

Molecular Profile BRAF V600E
Therapy Gedatolisib
Indication/Tumor Type colon cancer
Response Type sensitive
Create By c-seddy
Update By c-seddy

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E colon cancer sensitive Gedatolisib Preclinical Actionable In a preclinical study, Gedatolisib (PKI-587) inhibited Braf V600E in vitro and inhibited growth of human colon cancer cells harboring BRAF V600E in culture (PMID: 21325073, PMID: 24042735). 24042735 21325073
PubMed Id Reference Title Details
(21325073) Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor. Full reference...
(24042735) Epigenetic and genetic features of 24 colon cancer cell lines. Full reference...