Profile Response Detail

Molecular Profile CTNNB1 mutant
Therapy BC21
Indication/Tumor Type colorectal cancer
Response Type sensitive
Create By spatterson
Update By spatterson

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 mutant colorectal cancer sensitive BC21 Preclinical Actionable In a preclinical study, BC21 inhibited growth and viability of a colorectal cancer cell line with a CTNNB1 mutation and increased beta-catenin expression in culture (PMID: 22224445). 22224445
PubMed Id Reference Title Details
(22224445) Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. Full reference...