Profile Response Detail

Molecular Profile APC inact mut
Therapy G007-LK
Indication/Tumor Type colon cancer
Response Type sensitive
Create By spatterson
Update By cstatz


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC inact mut colon cancer sensitive G007-LK Preclinical - Cell line xenograft Actionable In a preclinical study, G007-LK inhibited growth of APC-mutant colorectal cancer cell lines in culture and in xenograft models (PMID: 23539443). 23539443
PubMed Id Reference Title Details
(23539443) A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Full reference...