Profile Response Detail

Molecular Profile ERBB2 amp
Therapy Cetuximab
Indication/Tumor Type colorectal cancer
Response Type resistant
Create By c-tyin
Update By spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB2 amp colorectal cancer resistant Cetuximab Clinical Study Actionable In a clinical study, ERBB2 (HER2) amplification was associated with resistance to Erbitux (cetuximab) in colorectal cancer patients (PMID: 21900593). 21900593
PubMed Id Reference Title Details
(21900593) Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Full reference...