Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Molecular Profile||FGFR3 G384D FGFR3 over exp|
|Indication/Tumor Type||multiple myeloma|
|Response Type||decreased response|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR3 G384D FGFR3 over exp||multiple myeloma||decreased response||AZD4547||Preclinical||Actionable||In a preclinical study, multiple myeloma cells over expressing FGFR3 G384D had reduced sensitivity to AZD4547 in culture, compared to cells with ligand-independent activation of FGFR3 (PMID: 22869148).||22869148|
|PubMed Id||Reference Title||Details|
|(22869148)||Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance.||Full reference...|