Profile Response Detail

Molecular Profile BRAF V600X
Therapy Vemurafenib
Indication/Tumor Type colorectal cancer
Response Type no benefit
Create By spatterson
Update By spatterson


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600X colorectal cancer no benefit Vemurafenib Phase II Actionable In a Phase II clinical trial, treatment with Zelboraf (vemurafenib) in colorectal cancer patients with BRAF V600 mutations did not result in clinical benefit, with no patients achieving response, and 50% (5/10) demonstrating progressive disease (PMID: 26287849). 26287849
PubMed Id Reference Title Details
(26287849) Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations. Full reference...