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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|NRAS Q61L||melanoma||resistant||PLX4720||Preclinical - Cell line xenograft||Actionable||In a preclinical study, PLX4720 did not inhibit growth of melanoma cells harboring NRAS Q61L in culture or in cell line xenograft models (PMID: 25500121, PMID: 23431193).||25500121 23431193|
|PubMed Id||Reference Title||Details|
|(25500121)||Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.||Full reference...|
|(23431193)||Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.||Full reference...|