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Molecular Profile ASXL1 inact mut
Therapy N/A
Indication/Tumor Type myelodysplastic/myeloproliferative neoplasm
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ASXL1 inact mut myelodysplastic/myeloproliferative neoplasm not applicable N/A Clinical Study Prognostic In multiple clinical studies, nonsense and frameshift mutations in ASXL1 were associated with decreased overall survival in patients with chronic myelomonocytic leukemia (PMID: 26849014, PMID: 23690417, PMID: 20880116). 20880116 26849014 23690417
PubMed Id Reference Title Details
(20880116) ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia. Full reference...
(26849014) Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia. Full reference...
(23690417) Prognostic score including gene mutations in chronic myelomonocytic leukemia. Full reference...