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Molecular Profile CBL mutant
Therapy N/A
Indication/Tumor Type myelodysplastic/myeloproliferative neoplasm
Response Type not applicable

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CBL mutant myelodysplastic/myeloproliferative neoplasm not applicable N/A Clinical Study Prognostic In clinical analyses, mutations in CBL were associated with adverse prognosis in patients with chronic myelomonocytic leukemia (PMID: 26230957, PMID: 23690417, PMID: 19901108). 26230957 19901108 23690417
PubMed Id Reference Title Details
(26230957) An international data set for CMML validates prognostic scoring systems and demonstrates a need for novel prognostication strategies. Full reference...
(23690417) Prognostic score including gene mutations in chronic myelomonocytic leukemia. Full reference...
(19901108) Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. Full reference...