Profile Response Detail

Molecular Profile FLT3 exon 14 ins
Therapy Cabozantinib
Indication/Tumor Type Advanced Solid Tumor
Response Type predicted - sensitive
Create By cms
Update By djd

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins Advanced Solid Tumor predicted - sensitive Cabozantinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing a FLT3-ITD mutation were sensitive to Cometriq (cabozantinib) in culture (PMID: 21926191). 21926191
PubMed Id Reference Title Details
(21926191) Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Full reference...