Profile Response Detail

Molecular Profile KIT D816V
Therapy Imatinib
Indication/Tumor Type Advanced Solid Tumor
Response Type resistant
Create By spatterson
Update By spatterson


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT D816V Advanced Solid Tumor resistant Imatinib Preclinical Actionable In a preclinical study, transformed cells expressing KIT D816V demonstrated resistance to Gleevec (imatinib mesylate) in culture (PMID: 15790786). 15790786
PubMed Id Reference Title Details
(15790786) Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Full reference...