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Molecular Profile CDH1 over exp
Therapy Erlotinib + Selumetinib
Indication/Tumor Type pancreatic ductal adenocarcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDH1 over exp pancreatic ductal adenocarcinoma sensitive Erlotinib + Selumetinib Phase II Actionable In a Phase II clinical trial, patients with pancreatic ductal adenocarcinoma tumors expressing high levels of Cdh1 were more likely to respond to a combination therapy of Tarceva (erlotinib) and Selumetinib (AZD6244) (PMID: 26251290). 26251290
PubMed Id Reference Title Details
(26251290) A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma. Full reference...