Profile Response Detail

Molecular Profile SMAD4 dec exp
Therapy N/A
Indication/Tumor Type colorectal cancer
Response Type not applicable
Create By smockus
Update By spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMAD4 dec exp colorectal cancer not applicable N/A Clinical Study Prognostic In clinical and meta-analyses, decreased expression of Smad4 was correlated with poor prognosis in colorectal cancer (PMID: 25749173, PMID: 19478385, PMID: 25681512, PMID: 26861460). 25749173 19478385 26861460 25681512
PubMed Id Reference Title Details
(25749173) A Meta-Analysis of SMAD4 Immunohistochemistry as a Prognostic Marker in Colorectal Cancer. Full reference...
(26861460) Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer. Full reference...
(25681512) Smad4 inactivation predicts for worse prognosis and response to fluorouracil-based treatment in colorectal cancer. Full reference...
(19478385) Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients. Full reference...