Profile Response Detail

Molecular Profile TP53 R175H
Therapy ReACp53
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By spatt
Update By spatt

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 R175H Advanced Solid Tumor sensitive ReACp53 Preclinical Actionable In a preclinical study, treatment with ReACp53 induced cell death in primary human uterine fibroblasts expressing TP53 R175H in culture (PMID: 26748848). 26748848
PubMed Id Reference Title Details
(26748848) A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Full reference...