Profile Response Detail


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Molecular Profile FGFR3 - TACC3
Therapy Erdafitinib
Indication/Tumor Type glioblastoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 - TACC3 glioblastoma predicted - sensitive Erdafitinib Case Reports/Case Series Actionable In a Phase I trial, Balversa (erdafitinib) treatment resulted in partial response in a glioblastoma patient harboring FGFR3-TACC3 fusion (PMID: 26324363; NCT01703481). 26324363
FGFR3 - TACC3 glioblastoma predicted - sensitive Erdafitinib Case Reports/Case Series Actionable In a clinical study, Balversa (erdafitinib) treatment resulted in tumor reduction and stable disease in 2 glioblastoma multiforme patients harboring FGFR3-TACC3 fusion (PMID: 25609060). 25609060
PubMed Id Reference Title Details
(26324363) Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors. Full reference...
(25609060) Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma. Full reference...