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Molecular Profile | FGFR3 - TACC3 |
Therapy | Erdafitinib |
Indication/Tumor Type | high grade glioma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 - TACC3 | high grade glioma | sensitive | Erdafitinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Balversa (erdafitinib) inhibited proliferation of glioma cells harboring FGFR3-TACC3 fusion in culture and xenograft tumor growth in animal models (PMID: 25609060). | 25609060 |
PubMed Id | Reference Title | Details |
---|---|---|
(25609060) | Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma. | Full reference... |