Profile Response Detail

Molecular Profile FGFR3 fusion
Therapy TAS-120
Indication/Tumor Type Advanced Solid Tumor
Response Type predicted - sensitive
Create By spatt
Update By djd

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 fusion Advanced Solid Tumor predicted - sensitive TAS-120 Preclinical - Cell line xenograft Actionable In a preclinical study, TAS-120 demonstrated growth inhibition and reduced FGFR phosphorylation in human cancer cell lines and xenograft models harboring FGFR mutations (Mol Cancer Ther 2013;12(11 Suppl):A270). detail...
PubMed Id Reference Title Details
TAS-120, a highly potent and selective irreversible FGFR inhibitor, is effective in tumors harboring various FGFR gene abnormalities Full reference...