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Molecular Profile | FGFR3 - TACC3 |
Therapy | FIIN-1 |
Indication/Tumor Type | urinary bladder cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 - TACC3 | urinary bladder cancer | sensitive | FIIN-1 | Preclinical | Actionable | In a preclinical study, FIIN-1 inhibited growth of the RT4 bladder cancer cell line, which has been demonstrated to harbor an FGFR3-TACC3 fusion, in culture (PMID: 20338520, PMID: 23175443). | 23175443 20338520 |
PubMed Id | Reference Title | Details |
---|---|---|
(20338520) | A structure-guided approach to creating covalent FGFR inhibitors. | Full reference... |
(23175443) | Oncogenic FGFR3 gene fusions in bladder cancer. | Full reference... |