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Molecular Profile | NOTCH1 rearrange |
Therapy | MRK-003 |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NOTCH1 rearrange | triple-receptor negative breast cancer | sensitive | MRK-003 | Preclinical | Actionable | In a preclinical study, MRK-003 inhibited growth of triple receptor-negative breast cancer cells harboring NOTCH1 rearrangement in culture and reduced tumor growth in xenograft models (PMID: 25104330). | 25104330 |
PubMed Id | Reference Title | Details |
---|---|---|
(25104330) | Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. | Full reference... |