Profile Response Detail


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Molecular Profile PTEN dec exp
Therapy Pembrolizumab
Indication/Tumor Type melanoma
Response Type decreased response


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN dec exp melanoma decreased response Pembrolizumab Clinical Study - Cohort Actionable In a clinical study, melanoma patients with PTEN expression in less than 10% of tumor cells demonstrated decreased response to anti-PD-1 antibodies, including Keytruda (pembrolizumab), compared to patients in which PTEN is present in over 10% of tumor cells (PMID: 26645196). 26645196
PubMed Id Reference Title Details
(26645196) Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy. Full reference...