Profile Response Detail


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Molecular Profile BRAF V600E
Therapy TW-37 + Vemurafenib
Indication/Tumor Type lung non-small cell carcinoma
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E lung non-small cell carcinoma sensitive TW-37 + Vemurafenib Preclinical Actionable In a preclinical study, TW-37 enhanced the inhibitory effect of Zelboraf (vemurafenib) on human non-small cell lung cancer cells harboring BRAF V600E in culture (PMID: 25665005). 25665005
PubMed Id Reference Title Details
(25665005) The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Full reference...